Unveiled at the 2011 24 Hours of Le Mans, the R8 GT Spyder is the convertible version of the R8 GT. Limited to 333 units worldwide, the R8 GT Spyder combines the aggressiveness of the R8 GT with an open top driving experience. Aside from the roof, the only performance related change is the change in weight which has increased to 1,640 kg (3,616 lb) (dry weight). The engine frame is made of ultra-light magnesium; the soft top cover and the large side panels at the rear are made of carbon fibre reinforced polymer (CFRP). CFRP is also used for the modified front spoiler, the fixed rear spoiler and the new rear bumper; even the seats used are made of carbon fibre which result in a weight saving of 70 lb (32 kg) alone. Together, these components provide a weight saving of 85 kg (187 lb) over the standard V10 Spyder. Visual changes include add-on parts in contrasting titanium gray, a front splitter with a dual lip, flics at the sides of the front bumper, red GT badges, round exhaust tailpipes, an enlarged rear diffuser and tinted LED tail lights in a clear-glass design. A CFRP windshield frame is also available as an option.

US model went on sale as a 2012 Model Year car, with delivery beginning in February 2012. Only 50 units were sold in the US.