The D4 series Audi S8 4.0 TFSI quattro went on sale in 2012. Like the previous iteration, the S8 costs less than the A8 L W12.

The S8 can accelerate from 0 to 100 km/h (0 to 62 mph) in 4.2 seconds. It is powered by a 4.0-litre TFSI biturbo V8 engine with 382 kW (512 hp). The engine utilises cylinder deactivation so it can run as a V4 for better fuel economy. The S8's engine is shared with the Bentley Continental GT, while a detuned variant of the engine makes 420 hp which is found in the 2013 Audi S6, Audi S7, and Audi A8. Direct competitors include the BMW Alpina B7 and Mercedes-Benz S63 AMG, which also have biturbo V8 engines.

The vehicle was unveiled at the 2011 Frankfurt Auto Show, and went on sale in spring 2012.

Taiwan models went on sale in 2013.